Atrial fibrillation (AF) is an arrhythmia affecting millions of patients and is often treated with a procedure called pulmonary vein isolation. Traditionally, extreme heating or cooling is employed to achieve the desired effect of blocking abnormal heartbeats. However, these thermal methods may carry risk to surrounding structures such as the esophagus and phrenic nerve.1 FARAPULSE Pulsed Field Ablation (PFA) is a novel, non-thermal method for cardiac ablation that is fundamentally different from traditional modalities.
FARAPULSE PFA is the momentary creation of a therapeutic electric field by a purpose-built catheter inside the heart. Through a process called irreversible electroporation, cardiac tissue targeted for ablation is rendered electrically inactive while collateral tissues are spared. Unlike traditional thermal methods, which ablate indiscriminately with extreme temperatures, non-thermal FARAPULSE PFA is tissue-selective.2,3
1 - Calkins H, Hindricks G, Cappato R, et al. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation. Heart Rhythm. 2017;14(10):e275-e444. doi:10.1016/j.hrthm.2017.05.012
2 - Reddy VY, Neuzil P, Koruth JS, et al. Pulsed Field Ablation for Pulmonary Vein Isolation in Atrial Fibrillation. J Am Coll Cardiol. 2019;74(3):315-326. doi:10.1016/j.jacc.2019.04.021
3 - Cochet H, Nakatani Y, Sridi-Cheniti S, et al. Pulsed field ablation selectively spares the oesophagus during pulmonary vein isolation for atrial fibrillation [published online ahead of print, 2021 May 7]. Europace. 2021;euab090. doi:10.1093/europace/euab090